On science and philosophy
Yakura H (2020) Immunity in light of Spinoza and Canguilhem. Philosophies 5: 38
Yakura H (2020) Cognitive and memory functions in plant immunity. Vaccines 8: 541
Yakura H (2019) Response to Fred Keijzer’s comments. Adaptive Behavior 27: 179-180
Yakura H (2019) A hypothesis: CRISPR-Cas as a minimal cognitive system. Adaptive Behavior 27: 167-173
Yakura H (2014) La médecine avec la vie contemplative. THE LUNG perspectives 22: 107-110
Yakura H (2013) Philosophical problems in neuropsychology. Jpn J Neuropsychology 29: 35-43
Yakura H & Shimaoka M (2013) Un dialogue. Etudier à l’étranger comme une pratique des arts libéraux. J Clin Exp Med 245: 1043-1053
Yakura H (2011) A “thought collective” around the idiotype network theory. BioEssays 33: 552-554
Before retiring from science
Harumiya S, Yoshino A, Hayashizaki K, Mizuno K, Yakura H, Adachi T (2013) A system for reconstructing B cell antigen receptor signaling in the mouse myeloma J558L cell line. Arch Biochem Biophys 533: 18-24
Nakata K, Suzuki Y, Inoue T, Ra C, Yakura H & Mizuno K (2011) Deficiency of SHP1 leads to sustained and increased ERK activation in mast cells, thereby inhibiting IL-3-dependent proliferation and cell death. Mol Immunol 48: 472–480
Akimoto M, Mishra K, Lim K-T, Tani N, Hisanaga S, Katagiri T, Elson A, Mizuno K & Yakura H (2009) Protein tyrosine phosphatase ε is a negative regulator of FcεRI-mediated mast cell responses. Scand J Immunol 69: 401-411
Nakata K, Yoshimaru T, Suzuki Y, Inoue T, Ra C, Yakura H & Mizuno K (2008) Positive and negative regulation of high affinity IgE receptor-signaling by Src homology region 2 domain-containing phosphatase 1. J Immunol 181: 5414-5424
Ozawa T, Nakata K, Mizuno K & Yakura H (2007) Negative autoregulation of Src homology region 2-domain-containing phosphatase 1 in rat basophilic leukemia-2H3 cells. Int Immunol 19: 1049-1061
Mizuno K, Tagawa Y, Watanabe N, Ogimoto M & Yakura H (2005) SLP-76 is recruited to CD22 and dephosphorylated by SHP-1, thereby regulating B cell receptor-induced c-Jun N-terminal kinase activation. Eur J Immunol 35: 644-654
Ogimoto M, Ichinowatari G, Watanabe N, Tada N, Mizuno K & Yakura H (2004) Impairment of B cell receptor-mediated Ca2+ influx, activation of mitogen-activated protein kinases and growth inhibition in CD72-deficient BAL-17 cells. Int Immunol 16: 971-982
Shrivastava P, Katagiri T, Ogimoto M, Mizuno K & Yakura H (2004) Dynamic regulation of Src-family kinases by CD45 in B cells. Blood 103: 1425-1432
Mizuno K, Tagawa Y, Mitomo K, Watanabe N, Katagiri T, Ogimoto M & Yakura H (2002) Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase. J Immunol 169: 778-786
Adachi T, Wienand J, Wakabayashi C, Yakura H, Reth M & Tsubata T (2001) SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem 276: 26648-26655
Arimura Y, Ogimoto M, Mitomo K, Katagiri T, Yamamoto K, Volarevic S, Mizuno K & Yakura H (2001) CD45 is required for CD40-induced inhibition of DNA synthesis and regulation of c-Jun NH2-terminal kinase and p38 in BAL-17 B cells. J Biol Chem 276: 8550-8556
Ogimoto M, Arimura Y, Katagiri T, Mitomo K, Woodgett JR, Nebreda AR, Mizuno K & Yakura H (2001) Opposing regulation of B cell receptor induced activation of mitogen activated protein kinases by CD45. FEBS Lett 490: 97-101
Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR & Kikutani H (2000) Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: A novel mechanism for regulating B cell signaling. Immunity 13: 621-631
Mizuno K, Tagawa Y, Mitomo K, Arimura Y, Hatano N, Katagiri T, Ogimoto M & Yakura H (2000) Src homology 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells. J Immunol 165: 1344-1351
Uetani N, Kato K, Ogura H, Mizuno K, Kawano K, Mikoshiba K, Yakura H, Asano M & Iwakura Y (2000) Impaired learning with enhanced hippocampal long-term potentiation in PTP-deficient mice. EMBO J 19: 2775-2785
Adachi T, Wakabayashi C, Yakura H & Tsubata T (1999) CD72 negatively regulates signaling through the antigen receptor of B cells. J Immunol 164: 1223-1229
Katagiri T, Ogimoto M, Hasegawa K, Arimura Y, Mitomo K, Okada M, Clark MR, Mizuno K & Yakura H (1999) CD45 negatively regulates Lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells. J Immunol 163: 1321-1326
Hasegawa K, Yajima H, Katagiri T, Ogimoto M, Arimura Y, Mitomo K, Mashima K, Mizuno K & Yakura H (1999) Requirement of PEST domain tyrosine phosphatase PEP in B cell antigen receptor-induced growth arrest and apoptosis. Eur J Immunol 29: 887-896
Adachi T, Flaswinkel H, Yakura H, Reth M & Tsubata T (1998) The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol 160: 4662-4665